Population genetics of apolipoprotein A-4, E, and H polymorphisms in Yanomami Indians of Northwestern Brazil: associations with lipids, lipoproteins, and carbohydrate metabolism
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1993
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Wayne State University Press
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Ohio State University. Departments of Anthropology and Preventive Medicine. Columbus, OH, USA.
University of Pittsburgh. Graduate School of Public Health. Department of Human Genetics. Pittsburgh, PA, USA.
University Hospital Rio de Janeiro. Community Health Service. Rio de Janeiro, RJ, Brasil.
Mayo Clinic. Division of Cardiovascular Diseases. Rochester, MN, USA.
University of Pittsburgh. Graduate School of Public Health. Department of Human Genetics. Pittsburgh, PA, USA.
University Hospital Rio de Janeiro. Community Health Service. Rio de Janeiro, RJ, Brasil.
Mayo Clinic. Division of Cardiovascular Diseases. Rochester, MN, USA.
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Abstract
Abstract
Using isoelectric focusing and immunoblotting techniques, we screened 96 serum samples from Yanomami Indians of northwestern Brazil to determine structural variation at three apolipoprotein loci: A4, E, and H. The APO-H locus, which is commonly polymorphic in white and black samples, was found to be monomorphic. At the APO-E locus only two alleles, APOE*3 and APOE*4 , rather than the three-allele polymorphism commonly seen in Caucasians, was observed. At the APO-A4 locus no example of the APOA4*2 allele, found in Caucasians, was detected. However, the frequency of the less common APOA4*4 allele was above what has been observed in any other population. We investigated the impact of genetic variation at both polymorphic loci on quantitative differences in lipids, apolipoproteins, serum glucose, glycated hemoglobin, and uric acid. Contrary to the cholesterol-elevating effect of APOE*4 reported elsewhere, in both univariate analyses and after adjustments for age, sex, weight, and height, APOE*4 was associated with about a 4% lower mean serum cholesterol. Only after adjustment was this association statistically significant. The APOE*4 allele was significantly associated with unadjusted APO-A1 and APOE levels but not with any other dependent variable; associations with adjusted APO-A1, APO-C2, and uric acid also approached standard levels of statistical significance ( p < 0.05). In univariate analyses the APOA4*4 allele was significantly associated with APO-B, serum glucose, percent glycated hemoglobin, and uric acid, but no significant associations were observed after dependent variables were adjusted for age, sex, weight, and height. These results support the notion that apolipoprotein distributions and their associations with lipid and carbohydrate metabolism show ethnic variability.
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Yanomami, Região Noroeste, Genética Humana
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Brasil, Saúde de Populações Indígenas, Índios Sul-Americanos, Doenças Cardiovasculares, Immunoblotting, Metabolismo dos Carboidratos, Variação Genética, Colesterol
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CREWS, Douglas E. et al. Population genetics of apolipoprotein A-4, E, and H polymorphisms in Yanomami Indians of Northwestern Brazil: associations with lipids, lipoproteins, and carbohydrate metabolism. Human Biology, v. 65, n. 2, p. 211-224, Apr. 1993.
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0018-7143