Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1088
Title: Brief Commuunication: Variability of innate immune system genes in Native American populations-relationship with history and epidemiology
Authors: Lindenau, Juliana Dal-Ri
Salzano, Francisco M.
Hurtado, Ana Magdalena
Hill, Kim R.
Petzl-Erler, Maria Luiza
Tsuneto, Luiza Tamie
Hutz, Mara Helena
Affilliation: Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Arizona State University. School of Human Evolution and Social Change. Tempe, AZ, EUA
Arizona State University. School of Human Evolution and Social Change. Tempe, AZ, EUA
Universidade Federal do Paraná. Departamento De Genética. Curitiba, PR, Brasil
Universidade Estadual De Maringá. Departamento de Análises Clínicas. Maringá, PR, Brasil
Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Abstract: OBJECTIVES: The immune system of a host, defending him/her against invading pathogens, has two main subsystems: innate immunity and acquired immunity. There are several evidences showing that Native American populations are immunologically different from non-Native populations. Our aim was to describe the variability of innate immune system genes in Native American populations. MATERIALS AND METHODS: We investigated heterozygozities and patterns of population differentiation (FST ) of 14 polymorphisms related to the innate immune response in five Native American populations (Aché, Guarani-Kaiowá, Guarani-Ñandeva, Kaingang, and Xavante) and the results were compared with the three major world population data (YRI, CEU, and CHB) available at the 1,000 genomes database. RESULTS: Mean heterozygosities ranged between 0.241 ± 0.057 (Aché) and 0.343 ± 0.033 (Kaingang), but no significant differences were observed (Friedman test, P = 0.197). Mean heterozygosities were also not significantly different when Amerindians were pooled and compared with the 1000 genomes populations (Friedman test, P = 0.506). When the Native American populations were grouped as Amerindians, a significantly higher FST value (0.194) was observed between the Amerindian and African populations. The Ewens-Watterson neutrality test showed that these markers are not under strong selective pressure. DISCUSSION: Native American populations present similar levels of heterozygosity as those of other continents, but are different from Africans in the frequency of polymorphisms of innate immune genes. This higher differentiation is probably due to demographic processes that occurred during the out-of-Africa event.
Keywords: Brasil
Índios Sul-Americanos
Saúde de Populações Indígenas
Mato Grosso
Epidemiologia
Região Centro-Oeste
Mato Grosso do Sul
Paraná
Região Sul
Região Sudeste
São Paulo
Xavante
Santa Catarina
Kaingang
Rio Grande do Sul
Paraguai
Aché
Estudos Epidemiológicos
Genética Humana
Guarani-Kaiowá
Guarani-Ñandeva
Imunocompetência
Sistema Imunológico
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Epidemiologia
Estudos Epidemiológicos
Genética Humana
Imunocompetência
Sistema Imunológico
Issue Date: 2016
Publisher: American Association of Physical Anthropologists
Citation: LINDENAU, Juliana Dal-Ri; SALZANO, Francisco M.; HURTADO, Ana Magdalena; HILL, Kim R.; PETZL-ERLER, Maria Luiza; TSUNETO, Luiza Tamie; HUTZ, Mara Helena. Brief Communication: Variability of innate immune system genes in native american populations-relationship with history and epidemiology. American Journal of Physical Anthropology, v. 159, n. 4, p. 722-728, 2016.
metadata.dc.identifier.doi: 10.1002/ajpa.22917
ISSN: 1096-8644
Copyright: open access
Appears in Collections:EPI - Artigos de Periódicos
GH - Artigos de Periódicos

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