Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1143
Title: Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians
Authors: Hutz, Mara H.
Almeida, Silvana de
Coimbra Junior, Carlos E. A.
Santos, Ricardo Ventura
Salzano, Francisco M.
Affilliation: Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Museu Nacional, Departamento de Antropologia. Rio de Janeiro, RJ, Brasil
Abstract: Haplotype and allele frequencies for the dopamine D2 receptor gene (DRD2), dopamine D4 receptor gene (DRD4), and dopamine transporter protein gene (SLC6A3) were determined in 135 individuals from five Brazilian Indian tribes, and the results integrated with those previously presented for this ethnic group. DRD2 and DRD4 were highly polymorphic. Haplotypes including TaqI A1 at DRD2, and the seven repeat allele at DRD4 were the most frequent variants, while the SLC6A3 locus was monomorphic for the 10 repeat allele in South American Indians. Genetic distances and the corresponding neighbor-joining tree indicated a geographic dichotomy between North + Central American and South American natives, with the exception of the Wai Wai, who live north of the Amazon river and are grouped in the northern cluster. G(ST) estimates from these genes vary between 0.05 and 0.11 for North and South America, respectively, indicating a higher degree of differentiation of the latter groups. These results are in accordance with previous genetic data on other systems, as well as with the history and biodemographical data of South American Indians.
Keywords: Brasil
Índios Sul-Americanos
Região Norte
Saúde de Populações Indígenas
Mato Grosso
Região Amazônica
Pará
Região Centro-Oeste
Gavião
Suruí
Rondônia
Xavante
Zoró
Wai Wai
Genética Humana
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Ecossistema Amazônico
Genética Humana
Issue Date: 2000
Publisher: Wiley-Liss
Citation: HUTZ, Mara H. et al. Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians. American Journal of Human Biology, v. 12, n. 5, p. 638-645, 2000.
metadata.dc.identifier.doi: 10.1002/1520-6300(200009/10)12:5<638
ISSN: 1520-6300
Other Identifiers: 10.1002/1520-6300(200009/10)12:5<638
1520-6300
Copyright: open access
Appears in Collections:GH - Artigos de Periódicos

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