Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1154
Title: Apolipoprotein B genetic variability in Brazilian Indians
Authors: Kaufman, Letícia
Vargas, André F.
Coimbra Junior, Carlos E. A.
Santos, Ricardo Ventura
Salzano, Francisco M.
Hutz, Mara H.
Affilliation: Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Departamento de Endemias. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Museu Nacional. Departamento de Antropologia. Rio de Janeiro, RJ, Brasil
Abstract: Three apolipoprotein B restriction fragment length polymorphism (RFLPs) (XbaI, MspI, and EcoRI) and the signal peptide insertion-deletion polymorphism were investigated using the polymerase chain reaction in 140 individuals from 5 Brazilian Indian tribes. All studied markers were polymorphic in this ethnic group. The insertion allele 5' beta SP*29 at the signal peptide previously observed in Mexican Americans was detected in about 8% of the chromosomes of 2 tribes (Gavião and Zoró), therefore confirming the Amerindian origin of this allele. Negative linkage disequilibrium was observed between alleles at the signal peptide and the EcoRI polymorphism in all tribes. In 3 populations (Gavião, Suruí, and Zoró) a negative disequilibrium was also detected between the insertion-deletion signal peptide markers and the XbaI polymorphism. In the whole sample of Amerindians 14 of the 24 (58%) possible 4-marker extended haplotypes were identified, but only haplotype 2 (5' beta SP*24/*X+/*M+/*E+) and haplotype 5 (5' beta SP*27/*X-/*M+/*E+) were shared by all tribes. No associations between plasma lipid levels or body mass index and these polymorphisms were observed in this sample.
Keywords: Brasil
Região Norte
Saúde de Populações Indígenas
Mato Grosso
Região Centro-Oeste
Região Amazônica
Pará
Região Sul
Região Sudeste
Gavião
Suruí
Rondônia
Xavante
Zoró
Rio Grande do Sul
Wai Wai
Genética Humana
Rio de Janeiro
Indíos Sul-Americanos
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Ecossistema Amazônico
Genética Humana
Issue Date: 1999
Publisher: Wayne State University Press
Citation: KAUFMAN, Letícia. et al. Apolipoprotein B genetic variability in Brazilian Indians. Human Biology, v. 71, n. 1, p. 87-98, 1999.
ISSN: 187143
Other Identifiers: 187143
Copyright: open access
Appears in Collections:GH - Artigos de Periódicos

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