Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1240
Title: Fibroblast growth factor receptor 1 (FGFR1) variants and craniofacial variation in Amerindians and related populations
Authors: Gómez-Valdés, Jorge A.
Hünemeier, Tábita
Contini, Verônica
Acuña-Alonzo, Victor
Macin, Gastón
Ballesteros-Romero, Mónica
Corral, Pau
Ruiz-Linares, Andres
Sánchez-Mejorada, Gabriela
Canizales-Quinteros, Samuel
Martínez-Abadías, Neus
Salzano, Francisco M.
González-José, Rolando
Bortolini, Maria Cátira
Affilliation: Universidad Nacional Autonoma de Mexico. Faculta de Medicina. Departamento de Anatomia. Laboratório de Antropologia Fisica. Mexico City, Mexico
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Escuela Nacional de Antropologá e Historia. Laboratorio de Genética Molecular. Mexico City, Mexico / Instituto Nacional de Medicina Geno´mica, Mexico City, Mexico
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Universidad Pompeu Fabra. Department of Experimental and Health Sciences. Barcelona, Spain
University College London. Department of Genetics, Evolution and Environment. London, United Kingdom
Universidad Nacional Autonoma de Mexico. Faculta de Medicina. Departamento de Anatomia. Laboratório de Antropologia Fisica. Mexico City, Mexico
Universidad Nacional Autonoma de Mexico. Faculta de Medicina. Departamento de Anatomia. Laboratório de Antropologia Fisica. Mexico City, Mexico / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Unidad de Biologia Molecular y Medicina Genomica. Mexico City, Mexico
Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Spain
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Centro Nacional Patagónico, CONICET. Puerto Madryn, Argentina
Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Abstract: OBJECTIVES: The polymorphic site rs4647905 of the FGFR1 gene was previously associated with a decrease in cephalic index (CI). Here, we evaluate the relationships between genotypes and cephalometric measurements and indices in one Mexican Native and two mestizo Mexican populations using two haplotype-tag SNPs (rs4647905 and rs3213849) that represent >85% of the FGFR1 variability, plus three other SNPs (rs2293971, rs2304000, and rs930828) situated nearby. In addition, we genotyped five South American natives, two European, one African, and one Siberian populations to evaluate their intra and intercontinental population diversity. METHODS: The five SNPs were tested and the craniofacial measurements and indices were collected using standardized procedures. Principal Component Analysis was used to verify individual/population comparisons. Associations were performed through the generalized linear model (GLM), coefficient of determination R(2) and linear regression tests. RESULTS: We found a tendency for a decrease in CI in individuals homozygous for allele rs4647905C, regardless of the population to which they belong, though the effect is more pronounced in mestizo. When the GLM analyses were performed using the absolute/linear cephalometric measurements, a statistically significant association was found between four SNPs and head length in the mestizo population. CONCLUSIONS: FGFR1 polymorphisms, especially rs4647905, can have an important role in the normal human skull variation, primarily due to their influence in head length, which would affect other cephalometric absolute/linear measures as well as indices like CI as a result of the pervasive nature of the morphological integration that characterizes the human skull.
Keywords: Saúde de Populações Indígenas
Genética Populacional
México
Antropologia biológica
DeCS: Saúde de Populações Indígenas
Genética Populacional
México
Issue Date: 2013
Publisher: American Journal of Human Biology
Citation: GÓMEZ-VALDÉS, Jorge A. et al. Fibroblast growth factor receptor 1 (FGFR1) variants and craniofacial variation in amerindians and related populations. American Journal of Human Biology, v. 25, n. 1, p. 12-19, 2013.
metadata.dc.identifier.doi: 10.1002/ajhb.22331
ISSN: 1520-6300
Copyright: open access
Appears in Collections:AN - Artigos de Periódicos

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