Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1257
Title: Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the Amazon Region of Brazil
Authors: Tavares, Edelweiss F.
Vieira-Filho, João P. B.
Andriolo, Adagmar
Sañudo, Adriana
Gimeno, Suely G. A.
Franco, Laércio J.
Affilliation: Universidade Federal de São Paulo. Departamento de Medicina. Seção de Endocrinologia. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Departamento de Medicina. Seção de Endocrinologia. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Departamento de Medicina. Seção de Patologia Clínica. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Departamento de Medicina. Seção de Patologia Clínica. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Departamento de Medicina. Seção de Patologia Clínica. São Paulo, SP, Brasil
Universidade Federal de São Paulo. Departamento de Medicina. Seção de Patologia Clínica. São Paulo, SP, Brasil
Abstract: The Parkatêjê Indians, belonging to the Jê group and inhabiting the Mãe Maria Reservation in the southeast of the state of Pará in the Amazon Region of Brazil, have suffered rapid and intensive cultural changes in recent years. This survey was designed to characterize the metabolic profile and the frequency of cardiovascular risk factors in this community. Ninety subjects (90.0% of the adult population without admixture) were investigated. Anthropometric measurements were performed and the following clinical characteristics measured: glycemia, serum insulin and proinsulin (fasting and 2-hr post 75 g of glucose load), beta-cell function (%B) and insulin sensitivity (%S) estimated by HOMA, HbA1c, GAD65 antibody, serum lipids, uric acid, creatinine, leptin, and blood pressure. Information about alcohol use, smoking, and medical history was obtained through individual interviews. The prevalences were: overweight, 67.8%; obesity, 14.4%; central obesity, 72.2%; hypertension, 4.4%; dyslipidemia, 44.4%; hyperuricemia, 5.6%; GAD65 antibody positivity, 4.4%; smoking, 25.6%; chronic alcohol use, 0.0%. One case of impaired glucose tolerance (1.1%) and one case of impaired fasting glycemia (1.1%) were diagnosed during this study and one case of diabetes (1.1%) was diagnosed previously. The diabetic woman was excluded from the analyses involving HbA1c, glycemia, insulin, proinsulin, %B, and %S. All creatinine values were normal. Blood pressure did not correlate with age, anthropometric measurements, insulin, proinsulin, and natural logarithm (ln) transformed %S. After adjustment for age and sex, there were positive correlations between total cholesterol and body mass index (BMI; r = 0.24), triglycerides and BMI (r = 0.44), triglycerides and waist-to-hip ratio (WHR; r = 0.52), In leptin and BMI (r = 0.41), In leptin and WHR (r = 0.29), uric acid and systolic blood pressure (r = 0.34), uric acid and triglycerides (r = 0.22). Systolic (r = 0.04; r = 0.70) and diastolic (r = 0.14; p = 0.18) blood pressure did not correlate with BMI. Ln leptin had a weak positive correlation with 2-hr insulin (r = 0.14) adjusted for age, sex, and BMI. The multiple linear regression model containing the variables sex, BMI, and 2-hr insulin concentrations explained 77.2% of the variation of ln leptin. In conclusion, the high rates of cardiovascular risk factors found among these Indians point to there being a high-risk group to develop diabetes and cardiovascular diseases. To reduce this risk they need to receive preventive interventions.
Keywords: Brasil
Índios Sul-Americanos
Região Norte
Saúde de Populações Indígenas
Região Amazônica
Epidemiologia
Pará
Diabetes Mellitus
Hipertensão
Antropometria
Fatores de Risco
Gavião Parkatêjê
Pressão Arterial
Índice de Massa Corporal
Avaliação Nutricional
Dislipidemias
Parkatêjê
Sobrepeso e Obesidade
Doenças Endócrinas, Nutricionais e Metabólicas
Doenças Crônicas não Transmissíveis
Doenças Cardiovasculares
Pressão Sanguínea
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Ecossistema Amazônico
Epidemiologia
Diabetes Mellitus
Hipertensão
Antropometria
Pressão Arterial
Índice de Massa Corporal
Dislipidemias
Doenças não Transmissíveis
Issue Date: 2003
Publisher: American Association of Anthropological Genetics
Citation: TAVARES, Edelweiss F.. et al. Metabolic profile and cardiovascular risk patterns of an Indian tribe living in the amazon region of Brazil. Human Biology, v. 75, n. 1, p. 31-46, 2003.
metadata.dc.identifier.doi: 10.1353/hub.2003.0028
Copyright: open access
Appears in Collections:AN - Artigos de Periódicos

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