Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1389
Title: High prevalence of HBV/A1 subgenotype in native south Americans may be explained by recent economic developments in the Amazon
Authors: Godoy, Bibiane A.
Gomes-Gouvêa, Michele S.
Zagonel-Oliveira, Marcelo
Alvarado-Mora, Mónica V.
Salzano, Francisco M.
Pinho, João R. R.
Fagundes, Nelson J. R.
Affilliation: Universidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasil
Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil
Universidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasil / Universidade do Vale do Rio dos Sinos. São Leopoldo, RS, Brasil
Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil
Universidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasil
Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil / Hospital Alberto Einstein. São Paulo, SP, Brasil
Universidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasil
Abstract: Native American populations present the highest prevalence of Hepatitis B Virus (HBV) infection in theAmericas, whichmay be associated to severe disease outcomes. Ten HBV genotypes (A–J) have been described, displaying a remarkable geographic structure, whichmost likely reflects historic patterns of humanmigrations. In this study, we characterize the HBV strains circulating in a historical sample of Native South Americans to characterize the historical viral dynamics in this population. The sample consisted of 1070 individuals belonging to 38 populations collected between 1965 and 1997. Presence of HBV DNA was checked by quantitative real-time PCR, and determination of HBV genotypes and subgenotypeswas performed through sequencing and phylogenetic analysis of a fragment including part of HBsAg and Pol coding regions (S/Pol). A Bayesian Skyline Plot analysiswas performed to compare the viral population dynamics of HBV/A1 strains found in Native Americans and in the general Brazilian population. A total of 109 individualswere positive for HBV DNA (~10%), and 70 sampleswere successfully sequenced and genotyped. Subgenotype A1 (HBV/A1), related to African populations and the African slave trade, was the most prevalent (66–94%). The Skyline Plot analysis showed a marked population expansion ofHBV/A1 in Native Americans occurringmore recently (1945–1965) than in the general Brazilian population. Our results suggest that historic processes that contributed to formation of HBV/A1 circulating in Native American are related with more recent migratory waves towards the Amazon basin, which generated a different viral dynamics in this region.
Keywords: Brasil
Índios Sul-Americanos
Saúde de Populações Indígenas
Região Amazônica
Região Centro-Oeste
Região Sudeste
Argentina
Migração
Paraguai
Hepatite B
Genética Humana
Genótipo
Doenças Infecciosas e Parasitárias
Bolívia
Uruguai
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Hepatite B
Genética Humana
Doenças Infecciosas
Vírus da Hepatite B
Issue Date: 2016
Publisher: Elsevier
Citation: GODOY, Bibiane A.; et al. High prevalence of HBV/A1 subgenotype in native south Americans may be explained by recent economic developments in the Amazon. Infection, Genetics and Evolution:, v. 43, p. 354-363, 2016.
metadata.dc.identifier.doi: 10.1016/j.meegid.2016.06.002
ISSN: 1567-7257
Copyright: open access
Appears in Collections:DIP - Artigos de Periódicos

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