Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1389
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dc.contributor.authorGodoy, Bibiane A.-
dc.contributor.authorGomes-Gouvêa, Michele S.-
dc.contributor.authorZagonel-Oliveira, Marcelo-
dc.contributor.authorAlvarado-Mora, Mónica V.-
dc.contributor.authorSalzano, Francisco M.-
dc.contributor.authorPinho, João R. R.-
dc.contributor.authorFagundes, Nelson J. R.-
dc.date.accessioned2019-12-04T17:16:48Z-
dc.date.available2019-12-04T17:16:48Z-
dc.date.issued2016-
dc.identifier.citationGODOY, Bibiane A.; et al. High prevalence of HBV/A1 subgenotype in native south Americans may be explained by recent economic developments in the Amazon. Infection, Genetics and Evolution:, v. 43, p. 354-363, 2016.en_US
dc.identifier.issn1567-7257-
dc.identifier.urihttp://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1389-
dc.language.isoeng-
dc.publisherElsevieren_US
dc.rightsopen accessen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherRegião Centro-Oesteen_US
dc.subject.otherRegião Sudesteen_US
dc.subject.otherArgentinaen_US
dc.subject.otherMigraçãoen_US
dc.subject.otherParaguaien_US
dc.subject.otherHepatite Ben_US
dc.subject.otherGenética Humanaen_US
dc.subject.otherGenótipoen_US
dc.subject.otherDoenças Infecciosas e Parasitáriasen_US
dc.subject.otherBolíviaen_US
dc.subject.otherUruguaien_US
dc.titleHigh prevalence of HBV/A1 subgenotype in native south Americans may be explained by recent economic developments in the Amazonen_US
dc.typeArticleen_US
dc.creator.affilliationUniversidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasil / Universidade do Vale do Rio dos Sinos. São Leopoldo, RS, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil / Hospital Alberto Einstein. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade do Rio Grande do Sul. Departamento de Genética.Porto Alegre, RS, Brasilen_US
dc.description.abstractenNative American populations present the highest prevalence of Hepatitis B Virus (HBV) infection in theAmericas, whichmay be associated to severe disease outcomes. Ten HBV genotypes (A–J) have been described, displaying a remarkable geographic structure, whichmost likely reflects historic patterns of humanmigrations. In this study, we characterize the HBV strains circulating in a historical sample of Native South Americans to characterize the historical viral dynamics in this population. The sample consisted of 1070 individuals belonging to 38 populations collected between 1965 and 1997. Presence of HBV DNA was checked by quantitative real-time PCR, and determination of HBV genotypes and subgenotypeswas performed through sequencing and phylogenetic analysis of a fragment including part of HBsAg and Pol coding regions (S/Pol). A Bayesian Skyline Plot analysiswas performed to compare the viral population dynamics of HBV/A1 strains found in Native Americans and in the general Brazilian population. A total of 109 individualswere positive for HBV DNA (~10%), and 70 sampleswere successfully sequenced and genotyped. Subgenotype A1 (HBV/A1), related to African populations and the African slave trade, was the most prevalent (66–94%). The Skyline Plot analysis showed a marked population expansion ofHBV/A1 in Native Americans occurringmore recently (1945–1965) than in the general Brazilian population. Our results suggest that historic processes that contributed to formation of HBV/A1 circulating in Native American are related with more recent migratory waves towards the Amazon basin, which generated a different viral dynamics in this region.en_US
dc.identifier.doi10.1016/j.meegid.2016.06.002-
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsHepatite Ben_US
dc.subject.decsGenética Humanaen_US
dc.subject.decsDoenças Infecciosasen_US
dc.subject.decsVírus da Hepatite Ben_US
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