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Title: Incidence and transmission patterns of tuberculosis among indigenous populations in Brazil
Authors: Cunha, Eunice Atsuko Totumi
Ferrazoli, Lucilaine
Riley, Lee W.
Basta, Paulo Cesar
Honer, Michael Robert
Maia, Rosalia
Costa, Izaias Pereira da
Affilliation: Laboratório Central de Saúde Pública de Mato Grosso do Sul. Seção de Micobacteriologia. Campo Grande, MS, Brasil.
Instituto Adolfo Lutz. Núcleo de Tuberculose e Micobacteriose. São Paulo, SP, Brasil.
University of California. School of Public Health. Division of Infectious Diseases & Vaccinology. Berkeley, CA, USA.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.
Universidade Católica Dom Bosco. Campo Grande, MS, Brasil.
Ministério da Saúde. Programa Nacional de Controle da Tuberculose. Brasilia, DF, Brasil.
Universidade Federal de Mato Grosso do Sul. Faculdade de Medicina. Campo Grande, MS, Brasil.
Abstract: Approximately 10% of the Brazilian indigenous population lives in the state of Mato Grosso do Sul (MS), where a large number of new cases of tuberculosis (TB) are reported. This study was conducted to assess TB occurrence, transmission and the utility of TB diagnosis based on the Ogawa-Kudoh (O-K) culture method in this remote population. The incidence of TB was estimated by a retrospective review of the surveillance data maintained by the Notifiable Diseases Surveillance System for the study region. The TB transmission pattern among indigenous people was assessed by genotyping Mycobacterium tuberculosis isolates using the IS6110 restriction fragment length polymorphism (RFLP) technique. Of the 3,093 cases identified from 1999-2001, 610 (~20%) were indigenous patients (average incidence: 377/100,000/year). The use of the O-K culture method increased the number of diagnosed cases by 34.1%. Of the genotyped isolates from 52 indigenous patients, 33 (63.5%) belonged to cluster RFLP patterns, indicating recently transmitted TB. These results demonstrate high, on-going TB transmission rates among the indigenous people of MS and indicate that new efforts are needed to disrupt these current transmissions.
Keywords: Brasil
Índios Sul-Americanos
Saúde de Populações Indígenas
Região Centro-Oeste
Mato Grosso do Sul
DSEI Mato Grosso do Sul
Serviços de Saúde
Genética Humana
Epidemiologia molecular
Sistemas de Informação em Saúde
Doenças Infecciosas e Parasitárias
Distrito Sanitário Especial Indígena
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Sistemas Locais de Saúde
Genética Humana
Epidemiologia molecular
Serviços de Saúde do Indígena
Doenças Infecciosas
Issue Date: 2014
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
Citation: CUNHA, Eunice Atsuko et al. Incidence and transmission patterns of tuberculosis among indigenous populations in Brazil. Memórias do Instituto Oswaldo Cruz, v. 109, n. 1, p. 108-113, 2014.
metadata.dc.identifier.doi: 10.1590/0074-0276130082
ISSN: 0074-0276
Copyright: open access
Appears in Collections:DIP - Artigos de Periódicos
EPI - Artigos de Periódicos

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