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Title:	Cytokine genes are associated with tuberculin skin test response in a native Brazilian population
Authors:	Zembrzuski, Verônica M. Basta, Paulo Cesar Callegari-Jacques, S. M. Santos, Ricardo Ventura Coimbra Junior, Carlos Everaldo Alvares Salzano, Francisco M. Hutz, Mara H.
Affilliation:	Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Estatística. Porto Alegre, RS, Brasil Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil Universidade Federal do Rio Grande do Sul. Instituto de Biociências. Departamento de Genética. Porto Alegre, RS, Brasil
Abstract:	Tuberculosis was a major cause of population decline among Brazilian indigenous peoples and remains a leading cause of morbidity and mortality among them. Despite high BCG coverage, results of Tuberculin Skin Test (TST) reactivity have shown high rates of anergy in Amazonian Indians. Given the high prevalence of anergy in these populations and the fact that genetic host factors play an important role in susceptibility to Mycobacterium tuberculosis (MTB), the aim of this study was to evaluate the association of nineteen polymorphisms in fifteen genes related to immune response and anergy in the Xavante, an indigenous group from Brazil. A total of 481 individuals were investigated. TST anergy was observed in 69% of them. Polymorphisms in four genes showed absence or very low variability: SP110, PTPN22, IL12RB1 and IL6. IFNG +874 A/T heterozygotes and IL4-590 C/C homozygotes were more frequent in those individuals who presented a positive TST (prevalence ratios of 1.9 and 2.0 respectively). The risk of anergy was 1.5 in IL10-1082 G/G homozygotes when compared to carriers for the A allele. In indigenous groups such as the Xavante exposure to a variety of infections, associated with specific genetic factors, may disturb the T-helper 1 and T-helper 2 balance leading to increased immunological susceptibility.
Keywords:	Brasil Índios Sul-Americanos Saúde de Populações Indígenas Mato Grosso Região Amazônica Epidemiologia Região Centro-Oeste Xavante Tuberculose Morbidade Genética Humana Mycobacterium tuberculosis Doenças Infecciosas e Parasitárias
DeCS:	Brasil Saúde de Populações Indígenas Índios Sul-Americanos Ecossistema Amazônico Tuberculose Morbidade Genética Humana Mycobacterium tuberculosis Epidemiologia Doenças Infecciosas
Issue Date:	2010
Publisher:	Elsevier
Citation:	ZEMBRZUSKI, Verônica M. et al. Cytokine genes are associated with tuberculin skin test response in a native Brazilian population. Tuberculosis (Edinburgh, Scotland), v. 90, n. 1, p. 44-49, 2010.
metadata.dc.identifier.doi:	10.1016/j.tube.2009.11.002
Copyright:	open access
Appears in Collections:	EPI - Artigos de Periódicos

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