Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1409
Title: Transmission of human herpesvirus type 8 infection within families in american indigenous populations from the Brazilian Amazon.
Authors: Borges, Jaila D.
Souza, Vanda A. U. F.
Giambartolomei, Claudia
Dudbridge, Frank
Freire, Wilton S.
Gregório, Shinai Arriel
Torrez, Pasesa Pascuala Quispe
Quiroga, Mariana
Mayaud, Philippe
Pannuti, Claudio S.
Nascimento, Maria Cláudia
Affilliation: Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil / Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). São Paulo, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil
London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health, Department of Non-communicable Disease Epidemiology. London, United Kingdom
London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health, Department of Non-communicable Disease Epidemiology. London, United Kingdom
Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil
London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdom
Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil
London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdom
Abstract: Background The intrafamilial dynamics of endemic infection with human herpesvirus type 8 (HHV-8) in Amerindian populations is unknown. Methods Serum samples were obtained from 517 Amerindians and tested for HHV-8 anti–latent nuclear antigen (anti-LANA) and antilytic antibodies by immunofluorescence assays. Logistic regression and mixed logistic models were used to estimate the odds of being HHV-8 seropositive among intrafamilial pairs. Results HHV-8 seroprevalence by either assay was 75.4% (95% confidence interval [CI]: 71.5%–79.1%), and it was age-dependent (Ptrend < 0.001). Familial dependence in HHV-8 seroprevalence by either assay was found between mother–offspring (odds ratio [OR], 5.44; 95% CI: 1.62–18.28) and siblings aged ≥10 years (OR 4.42, 95% CI: 1.70–11.45) or siblings in close age range (<5 years difference) (OR 3.37, 95% CI: 1.21–9.40), or in families with large (>4) number of siblings (OR, 3.20, 95% CI: 1.33–7.67). In separate analyses by serological assay, there was strong dependence in mother–offspring (OR 8.94, 95% CI: 2.94–27.23) and sibling pairs aged ≥10 years (OR, 11.91, 95% CI: 2.23–63.64) measured by LANA but not lytic antibodies. Conclusions This pattern of familial dependence suggests that, in this endemic population, HHV-8 transmission mainly occurs from mother to offspring and between close siblings during early childhood, probably via saliva. The mother to offspring dependence was derived chiefly from anti-LANA antibodies.
Keywords: Brasil
Índios Sul-Americanos
Região Norte
Saúde de Populações Indígenas
Região Amazônica
Epidemiologia
Pará
Tiriyó
Herpes
Wai Wai
Estudos Epidemiológicos
Doenças Infecciosas
Hixkariana
Katwena
Mawayana
Mawayána
Tunayana
Twnayana
Tyrió
Xereu
Xerew
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Ecossistema Amazônico
Epidemiologia
Herpesvirus Humano 8
Infecções por Herpesviridae
Issue Date: 2012
Publisher: Oxford University Press
Citation: BORGES, Jaila D.; et al. Transmission of human herpesvirus type 8 infection within families in american indigenous populations from the Brazilian Amazon. Journal of Infectious Diseases, v. 205, n. 12, p. 1869-1876, 2012.
metadata.dc.identifier.doi: 10.1093/infdis/jis278
ISSN: 0022-1899
Copyright: open access
Appears in Collections:DIP - Artigos de Periódicos

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