Please use this identifier to cite or link to this item:
http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1409
Title: | Transmission of human herpesvirus type 8 infection within families in american indigenous populations from the Brazilian Amazon. |
Authors: | Borges, Jaila D. Souza, Vanda A. U. F. Giambartolomei, Claudia Dudbridge, Frank Freire, Wilton S. Gregório, Shinai Arriel Torrez, Pasesa Pascuala Quispe Quiroga, Mariana Mayaud, Philippe Pannuti, Claudio S. Nascimento, Maria Cláudia |
Affilliation: | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil / Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). São Paulo, SP, Brasil Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health, Department of Non-communicable Disease Epidemiology. London, United Kingdom London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health, Department of Non-communicable Disease Epidemiology. London, United Kingdom Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdom Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil London School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdom |
Abstract: | Background The intrafamilial dynamics of endemic infection with human herpesvirus type 8 (HHV-8) in Amerindian populations is unknown. Methods Serum samples were obtained from 517 Amerindians and tested for HHV-8 anti–latent nuclear antigen (anti-LANA) and antilytic antibodies by immunofluorescence assays. Logistic regression and mixed logistic models were used to estimate the odds of being HHV-8 seropositive among intrafamilial pairs. Results HHV-8 seroprevalence by either assay was 75.4% (95% confidence interval [CI]: 71.5%–79.1%), and it was age-dependent (Ptrend < 0.001). Familial dependence in HHV-8 seroprevalence by either assay was found between mother–offspring (odds ratio [OR], 5.44; 95% CI: 1.62–18.28) and siblings aged ≥10 years (OR 4.42, 95% CI: 1.70–11.45) or siblings in close age range (<5 years difference) (OR 3.37, 95% CI: 1.21–9.40), or in families with large (>4) number of siblings (OR, 3.20, 95% CI: 1.33–7.67). In separate analyses by serological assay, there was strong dependence in mother–offspring (OR 8.94, 95% CI: 2.94–27.23) and sibling pairs aged ≥10 years (OR, 11.91, 95% CI: 2.23–63.64) measured by LANA but not lytic antibodies. Conclusions This pattern of familial dependence suggests that, in this endemic population, HHV-8 transmission mainly occurs from mother to offspring and between close siblings during early childhood, probably via saliva. The mother to offspring dependence was derived chiefly from anti-LANA antibodies. |
Keywords: | Brasil Índios Sul-Americanos Região Norte Saúde de Populações Indígenas Região Amazônica Epidemiologia Pará Tiriyó Herpes Wai Wai Estudos Epidemiológicos Doenças Infecciosas Hixkariana Katwena Mawayana Mawayána Tunayana Twnayana Tyrió Xereu Xerew |
DeCS: | Brasil Saúde de Populações Indígenas Índios Sul-Americanos Ecossistema Amazônico Epidemiologia Herpesvirus Humano 8 Infecções por Herpesviridae |
Issue Date: | 2012 |
Publisher: | Oxford University Press |
Citation: | BORGES, Jaila D.; et al. Transmission of human herpesvirus type 8 infection within families in american indigenous populations from the Brazilian Amazon. Journal of Infectious Diseases, v. 205, n. 12, p. 1869-1876, 2012. |
metadata.dc.identifier.doi: | 10.1093/infdis/jis278 |
ISSN: | 0022-1899 |
Copyright: | open access |
Appears in Collections: | DIP - Artigos de Periódicos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
989198323.pdf | 288.4 kB | Adobe PDF | ![]() View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.