Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1409
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dc.contributor.authorBorges, Jaila D.-
dc.contributor.authorSouza, Vanda A. U. F.-
dc.contributor.authorGiambartolomei, Claudia-
dc.contributor.authorDudbridge, Frank-
dc.contributor.authorFreire, Wilton S.-
dc.contributor.authorGregório, Shinai Arriel-
dc.contributor.authorTorrez, Pasesa Pascuala Quispe-
dc.contributor.authorQuiroga, Mariana-
dc.contributor.authorMayaud, Philippe-
dc.contributor.authorPannuti, Claudio S.-
dc.contributor.authorNascimento, Maria Cláudia-
dc.date.accessioned2019-12-10T12:22:12Z-
dc.date.available2019-12-10T12:22:12Z-
dc.date.issued2012-
dc.identifier.citationBORGES, Jaila D.; et al. Transmission of human herpesvirus type 8 infection within families in american indigenous populations from the Brazilian Amazon. Journal of Infectious Diseases, v. 205, n. 12, p. 1869-1876, 2012.en_US
dc.identifier.issn0022-1899-
dc.identifier.urihttp://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1409-
dc.language.isopor-
dc.publisherOxford University Pressen_US
dc.rightsopen accessen_US
dc.subject.otherBrasilen_US
dc.subject.otherÍndios Sul-Americanosen_US
dc.subject.otherRegião Norteen_US
dc.subject.otherSaúde de Populações Indígenasen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherEpidemiologiaen_US
dc.subject.otherParáen_US
dc.subject.otherTiriyóen_US
dc.subject.otherHerpesen_US
dc.subject.otherWai Waien_US
dc.subject.otherEstudos Epidemiológicosen_US
dc.subject.otherDoenças Infecciosasen_US
dc.subject.otherHixkarianaen_US
dc.subject.otherKatwenaen_US
dc.subject.otherMawayanaen_US
dc.subject.otherMawayánaen_US
dc.subject.otherTunayanaen_US
dc.subject.otherTwnayanaen_US
dc.subject.otherTyrióen_US
dc.subject.otherXereuen_US
dc.subject.otherXerewen_US
dc.titleTransmission of human herpesvirus type 8 infection within families in american indigenous populations from the Brazilian Amazon.en_US
dc.typeArticleen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasil / Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasilen_US
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health, Department of Non-communicable Disease Epidemiology. London, United Kingdomen_US
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health, Department of Non-communicable Disease Epidemiology. London, United Kingdomen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasilen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasilen_US
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdomen_US
dc.creator.affilliationUniversidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia (LIMHC), and Departamento de Moléstias Infecciosas e Parasitárias. São Paulo, SP, Brasilen_US
dc.creator.affilliationLondon School of Hygiene and Tropical Medicine. Faculty of Infectious and Tropical Diseases. London, United Kingdomen_US
dc.description.abstractenBackground The intrafamilial dynamics of endemic infection with human herpesvirus type 8 (HHV-8) in Amerindian populations is unknown. Methods Serum samples were obtained from 517 Amerindians and tested for HHV-8 anti–latent nuclear antigen (anti-LANA) and antilytic antibodies by immunofluorescence assays. Logistic regression and mixed logistic models were used to estimate the odds of being HHV-8 seropositive among intrafamilial pairs. Results HHV-8 seroprevalence by either assay was 75.4% (95% confidence interval [CI]: 71.5%–79.1%), and it was age-dependent (Ptrend < 0.001). Familial dependence in HHV-8 seroprevalence by either assay was found between mother–offspring (odds ratio [OR], 5.44; 95% CI: 1.62–18.28) and siblings aged ≥10 years (OR 4.42, 95% CI: 1.70–11.45) or siblings in close age range (<5 years difference) (OR 3.37, 95% CI: 1.21–9.40), or in families with large (>4) number of siblings (OR, 3.20, 95% CI: 1.33–7.67). In separate analyses by serological assay, there was strong dependence in mother–offspring (OR 8.94, 95% CI: 2.94–27.23) and sibling pairs aged ≥10 years (OR, 11.91, 95% CI: 2.23–63.64) measured by LANA but not lytic antibodies. Conclusions This pattern of familial dependence suggests that, in this endemic population, HHV-8 transmission mainly occurs from mother to offspring and between close siblings during early childhood, probably via saliva. The mother to offspring dependence was derived chiefly from anti-LANA antibodies.en_US
dc.identifier.doi10.1093/infdis/jis278-
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsEcossistema Amazônicoen_US
dc.subject.decsEpidemiologiaen_US
dc.subject.decsHerpesvirus Humano 8en_US
dc.subject.decsInfecções por Herpesviridaeen_US
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