DSpace JSPUI

1. BVS Saúde dos Povos Indígenas
2. Genética Humana (GH)
3. GH - Artigos de Periódicos

Title:	Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors
Authors:	Tavares, Edelweiss F. Vieira-Filho, João P. B. Andriolo, Adagmar Perez, Ana B. A. Vergani, Naja Sañudo, Adriana Gimeno, Suely G. A. Franco, Laércio J.
Affilliation:	Endocrinology Section and Clinic Pathology Section of Department of Medicine, Medical Genetics Center of Morphology and Pediatrics, and Department of Preventive Medicine, Federal University of São Paulo, São Paulo. SP, Brasil.
Abstract:	Hyperhomocysteinemia is a risk factor for cardiovascular disease. C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). Ninety Brazilian Parkatêjê Indians (90.0% of the population without admixture, aged > or = 20 years) were studied. Hyperhomocysteinemia was observed in 26.7% of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was found in 43.3% of the subjects. Rates of mutated allele 677T and TT genotype were 40.7% and 14.0%, respectively. Prevalence of hypertension, dyslipidemia, smoking, WHR > or = 0.9, BMI > or = 25 kg/m2 and chronic alcohol use were 4.4%, 44.4%, 25.6%, 72.2%, 67.8%, and 0.0%, respectively. All creatinine values were normal. Natural logarithmic (ln) tHcy showed no correlation with age, but was positively correlated with systolic (r = 0.22) and diastolic (r = 0.21) blood pressure and triglycerides (r = 0.39) and inversely correlated with folic acid (r = -0.40) adjusted for age and sex. Total homocysteine (tHcy) was higher among TT genotype (P < 0.001). The multiple linear regression model, containing variables for sex, folic acid, TT genotype, and triglycerides, explained 50.0% of the variation of the ln tHcy. In summary, high rates of cardiovascular risk factors were discovered. C667T mutation and folic acid deficiency can explain, at least in part, the observed hyperhomocysteinemia.
Keywords:	Brasil Índios Sul-Americanos Região Norte Saúde de Populações Indígenas Região Amazônica Epidemiologia Pará Antropometria Fatores de Risco Pressão Arterial Estudos Epidemiológicos Genética Humana Índice de Massa Corporal Avaliação Nutricional Dislipidemias Parkatêjê Deficiência de Vitaminas do Complexo B Deficiências Nutricionais Doenças Crônicas não Transmissíveis Doenças Cardiovasculares Deficiências de Micronutrientes Deficiência de Ácido Fólico Tabagismo
DeCS:	Brasil Saúde de Populações Indígenas Índios Sul-Americanos Ecossistema Amazônico Epidemiologia Antropometria Genética Humana Pressão Arterial Fatores de Risco
Issue Date:	2004
Publisher:	International Society on Hypertension in Blacks
Citation:	TAVARES, Edelweiss F.; et al. Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors. Ethnicity & Disease, v. 14, n. 1, p. 49-56, 2004.
ISSN:	1049-510X
Copyright:	open access
Appears in Collections:	GH - Artigos de Periódicos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.