Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1495
Title: Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors
Authors: Tavares, Edelweiss F.
Vieira-Filho, João P. B.
Andriolo, Adagmar
Perez, Ana B. A.
Vergani, Naja
Sañudo, Adriana
Gimeno, Suely G. A.
Franco, Laércio J.
Affilliation: Endocrinology Section and Clinic Pathology Section of Department of Medicine, Medical Genetics Center of Morphology and Pediatrics, and Department of Preventive Medicine, Federal University of São Paulo, São Paulo. SP, Brasil.
Abstract: Hyperhomocysteinemia is a risk factor for cardiovascular disease. C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). Ninety Brazilian Parkatêjê Indians (90.0% of the population without admixture, aged > or = 20 years) were studied. Hyperhomocysteinemia was observed in 26.7% of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was found in 43.3% of the subjects. Rates of mutated allele 677T and TT genotype were 40.7% and 14.0%, respectively. Prevalence of hypertension, dyslipidemia, smoking, WHR > or = 0.9, BMI > or = 25 kg/m2 and chronic alcohol use were 4.4%, 44.4%, 25.6%, 72.2%, 67.8%, and 0.0%, respectively. All creatinine values were normal. Natural logarithmic (ln) tHcy showed no correlation with age, but was positively correlated with systolic (r = 0.22) and diastolic (r = 0.21) blood pressure and triglycerides (r = 0.39) and inversely correlated with folic acid (r = -0.40) adjusted for age and sex. Total homocysteine (tHcy) was higher among TT genotype (P < 0.001). The multiple linear regression model, containing variables for sex, folic acid, TT genotype, and triglycerides, explained 50.0% of the variation of the ln tHcy. In summary, high rates of cardiovascular risk factors were discovered. C667T mutation and folic acid deficiency can explain, at least in part, the observed hyperhomocysteinemia.
Keywords: Brasil
Índios Sul-Americanos
Região Norte
Saúde de Populações Indígenas
Região Amazônica
Epidemiologia
Pará
Antropometria
Fatores de Risco
Pressão Arterial
Estudos Epidemiológicos
Genética Humana
Índice de Massa Corporal
Avaliação Nutricional
Dislipidemias
Parkatêjê
Deficiência de Vitaminas do Complexo B
Deficiências Nutricionais
Doenças Crônicas não Transmissíveis
Doenças Cardiovasculares
Deficiências de Micronutrientes
Deficiência de Ácido Fólico
Tabagismo
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Ecossistema Amazônico
Epidemiologia
Antropometria
Genética Humana
Pressão Arterial
Fatores de Risco
Issue Date: 2004
Publisher: International Society on Hypertension in Blacks
Citation: TAVARES, Edelweiss F.; et al. Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: the relationship of homocysteine with other cardiovascular risk factors. Ethnicity & Disease, v. 14, n. 1, p. 49-56, 2004.
ISSN: 1049-510X
Copyright: open access
Appears in Collections:GH - Artigos de Periódicos

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