Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/1496
Title: Genetic Clustering of Tuberculosis in an Indigenous Community of Brazil
Authors: Correia Sacchi, Flávia Patussi
Tatara, Mariana Bento
Camioli de Lima, Camila
Ferreia da Silva, Liliane
Cunha, Eunice Atsuko Totumi
Simonsen, Vera
Ferrazoli, Lucilaine
Gomes, Harrison Magdinier
Gonçalves Vasconcellos, Sidra Ezidio
Suffys, Philip Noel
Andrews, Jason R.
Croda, Julio Henrique Rosa
Affilliation: Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Universidade Federal de Grande Dourados. Dourados, MS, Brasil
Secretaria de Saúde Indígena. Dourados, MS, Brasil
Laboratório Central de Saúde Pública. Campo Grande, MS, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brasil
Universidade de Stanford. Escola de Medicina. Stanford, CA, Brasil
Fundação Oswaldo Cruz. Campo Grande, MS, Brasil
Abstract: We conducted a population-based study of tuberculosis (TB) from 2009 to 2015 in an indigenous community of Brazil, the largest in the country, to investigate risk factors associated with recent TB transmission. The clinical isolates of Mycobacterium tuberculosis were genotyped by IS6110-RFLP (restriction fragment length polymorphism) and spoligotyping analysis. Among 67 isolates typed by RFLP, 69% fell into fifteen clusters, and 91% of TB cases with shared IS6110-RFLP pattern were diagnosed within 2 years of another case in the cluster. Individual risk factors associated with genetic clustering were domestic overcrowding (odds ratio [OR]: 6.10; 95% confidence interval [CI]: 1.50-24.88) and low social class (OR: 3.72; 95% CI: 1.00-13.98). Most reported contacts (76%) were identified within the household of the index TB case, but most of the genetic clustering of M. tuberculosis occurred outside of household (79%). Expanded contacts investigation and prophylaxis outside of household should be considered as a priority for TB control programs in this population.
Keywords: Brasil
Índios Sul-Americanos
Saúde de Populações Indígenas
Epidemiologia
Tuberculose
Estudos Epidemiológicos
Genética Humana
Doenças Infecciosas
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Epidemiologia
Tuberculose
Genética Humana
Infecções Bacterianas
Issue Date: 2018
Publisher: American Society of Tropical Medicine and Hygiene
Citation: CORREIA SACCHI, Flávia Patussi; et al. Genetic clustering of tuberculosis in an indigenous community of Brazil. Am. J. Trop. Med. Hyg, v.98, n.2, p. 372-375, 2018.
metadata.dc.identifier.doi: 10.4269/ajtmh.17-0480
ISSN: 1476-1645
Copyright: open access
Appears in Collections:DIP - Artigos de Periódicos

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