Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/5106
Title: Impact of Latent Infection Treatment in Indigenous Populations
Authors: Yuhara, Lucia Suemi
Sacchi, Flávia Patussi Correia
Croda, Julio
Abstract: The aims of the present study were to identify risk factors associated with latent tuberculosis (TB), examine the development of active disease among contacts, and assess the effectiveness of treating latent infection in indigenous Brazilians from January 2006 to December 2011. This was a retrospective study consisting of 1,371 tuberculosis contacts, 392 of whom underwent treatment for latent infection. Morbidity-from-TB data were obtained from the Information System for Disease Notification (SINAN) database, and the contacts’ data were collected from the clinical records using forms employed by Special Department of Indigenous Health (SESAI) multidisciplinary teams, according to SESAI’s instructions. The variables that were associated with latent infection among the contacts were age (odds ratio [OR]: 1.03; 95% confidence interval [CI]: 1.02–1.04) and close contact with a smear-positive index case (OR: 2.26, 95% CI: 1.59–3.22). The variables associated with the development of active TB among the contacts were a tuberculin skin test (TST) ≥10 mm (relative risk [RR]: 1.12, 95% CI: 1.07–1.17), age (RR: 1.01, 95% CI: 1.00–1.03), and treatment of latent infection (RR: 0.03, 95% CI: 0.01–0.27). The estimated number of latent infection treatments needed to prevent one case of active TB among the contacts was 51 treatments (95% CI: 33–182). In contacts with TST ≥10 mm, 10 (95% CI: 6–19) latent infection treatments were necessary to prevent one case of active TB. Age and close contact with a smear-positive index case were associated with latent TB. Screening with TST is a high priority among individuals contacting smear-positive index cases. Age and TST are associated with the development of active TB among contacts, and treatment of latent infection is an effective measure to control TB in indigenous communities
Keywords: Brazil
Health of Indigenous Peoples
Indians, South American
Epidemiology
Latent Tuberculosis
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Epidemiologia
Tuberculose Latente
Tuberculose/TH
Issue Date: 2013
Publisher: Madhukar Pai, McGill University, Canada
Citation: YUHARA, Lucia Suemi; SACCHI, Flávia Patussi Correia; CRODA, Julio. Impact of Latent Infection Treatment in Indigenous Populations. PLoS ONE, v. 8, n. 7, p. e71201, 2013
metadata.dc.identifier.doi: 10.1371/journal.pone.0071201
ISSN: 1932-6203
Copyright: open access
Appears in Collections:DIP - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
110503642.pdf228.45 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.