Please use this identifier to cite or link to this item:
Title: Prevalence of anti-desmoglein-3 antibodies in endemic regions of fogo selvagem in Brazil
Authors: Hilario-Vargas, Julio
Dasher, David A.
Li, Ning
Aoki, Valeria
Hans-Filho, Gunter
Santos, Vandir dos
Qaqish, Bahjat F.
Rivitti, Evandro A.
Diaz, Luis A.
Abstract: Fogo selvagem (FS), the endemic form of pemphigus foliaceus (PF), is an autoimmune blistering disease characterized by autoantibodies against desmoglein 1. The Terena reservation of Limao Verde in Mato Grosso do Sul, Brazil, is a previously identified focus of disease. Autoantibodies against desmoglein 3 (Dsg3) have also been detected in sera from patients with FS. In an effort to further characterize the serological, geographical, and clinical epidemiology of the disease, we sought to determine the prevalence of anti-Dsg3 autoantibodies in sera from normal subjects living outside of and in an endemic area using an ELISA. Anti-Dsg3 antibodies were detected in 53 of 146 normal subjects from Limao Verde (36%), and in eight of 140 normal subjects from surrounding areas (6%). A significant trend was observed in the proportion of positive tests relative to distance from the endemic area (P<0.001). Our seroepidemiological observations support the concept that the likely environmental trigger of the antibody response in FS is located in this endemic area, and that the population at risk to develop FS may also be at risk to develop an endemic form of pemphigus vulgaris as reported by our co-investigators from Brasilia.
Keywords: Mato Grosso do Sul
Região Centro-Oeste
Fogo Selvagem
Pênfigo Vulgar
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Issue Date: 2006
Publisher: Elsevier
Citation: HILARIO-VARGAS, Julio; et al. Prevalence of anti-desmoglein-3 antibodies in endemic regions of fogo selvagem in Brazil. Journal of Investigative Dermatology, v. 126, n. 9, p. 2044-2048, 2006.
metadata.dc.identifier.doi: 10.1038/sj.jid.5700388
ISSN: 0022-202X
Copyright: open access
Appears in Collections:DIP - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
662842518.pdf110.1 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.