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Title: HPV Infection and Cervical Screening in Socially Isolated Indigenous Women Inhabitants of the Amazonian Rainforest
Authors: Fonseca, Allex Jardim
Taeko, Daniela
Chaves, Thiciane Araújo
Amorim, Lucia Dayanny da Costa
Murari, Raisa Saron Wanderley
Miranda, Angélica Espinosa
Chen, Zigui
Burk, Robert David
Ferreira, Luiz Carlos Lima
Abstract: Objective Indigenous women from the Amazon regions have some of the highest rates of cervical cancer in the world. This study evaluated cervical cytology and human papillomavirus (HPV) in native women that differ by lifestyle and interaction with western society. Yanomami women are isolated deep in the Amazon with a hunter/gatherer lifestyle. Macuxi and Wapishana women live in proximity to western society. Methods To select a representative group of women from each district, random cluster sampling was used, considering each registered village as a cluster. Cervical samples were collected for cytology and HPV detection and typing by PCR amplification and next generation sequencing. The study was approved by the National IRB and by tribal leaders. Results 664 native women were enrolled from 13 indigenous villages (76% participation rate). Yanomami women had higher rates of abnormal cytology (5.1% vs. 1.8%, p = 0.04) and prevalent HR-HPV (34.1% vs. 19.2%, p<0.001). Yanomami women >35y of age were significantly more likely to have HR-HPV, whereas women ≤35y did not significantly differ between groups. Prevalence of HPV was significantly different amongst geographically clustered Yanomami women (p<0.004). The most prevalent HPV types in the entire group were HPV31 (8.7%), HPV16 (5.9%) and HPV18 (4.4%). Conclusion Isolated endogenous Yanomami women were more likely to be HPV+ and rates increased with age. Study of HPV in isolated hunter-gather peoples suggests that long-term persistence is a characteristic of prehistoric humans and patterns reflecting decreased prevalence with age in western society represents recent change. These studies have implications for cervical cancer prevention and viral-host relationships.
Keywords: Brazil
Health of Indigenous Peoples
Indians, South American
Cluster Sampling
DNA, Viral
Keywords: Região Amazônica
Doenças e Agravos Não Transmissíveis
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Amostragem aleatória
DNA Viral
Issue Date: 2015
Publisher: Public Library of Science
Citation: FONSECA, Allex Jardim; TAEKO, Daniela; CHAVES, Thiciane Araújo; AMORIM, Lucia Dayanny da Costa; MURARI, Raisa Saron Wanderley; MIRANDA, Angélica Espinosa; CHEN, Zigui; BURK, Robert David; FERREIRA, Luiz Carlos Lima. HPV Infection and Cervical Screening in Socially Isolated Indigenous Women Inhabitants of the Amazonian Rainforest. PLoS ONE, v. 10, n. 7, p. e0133635 , 2015
metadata.dc.identifier.doi: 10.1371/journal.pone.0133635
ISSN: 1932-6203
Copyright: open access
Appears in Collections:DANT - Artigos de Periódicos

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