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dc.contributor.authorFonseca, Allex Jardim-
dc.contributor.authorTaeko, Daniela-
dc.contributor.authorChaves, Thiciane Araújo-
dc.contributor.authorAmorim, Lucia Dayanny da Costa-
dc.contributor.authorMurari, Raisa Saron Wanderley-
dc.contributor.authorMiranda, Angélica Espinosa-
dc.contributor.authorChen, Zigui-
dc.contributor.authorBurk, Robert David-
dc.contributor.authorFerreira, Luiz Carlos Lima-
dc.identifier.citationFONSECA, Allex Jardim; TAEKO, Daniela; CHAVES, Thiciane Araújo; AMORIM, Lucia Dayanny da Costa; MURARI, Raisa Saron Wanderley; MIRANDA, Angélica Espinosa; CHEN, Zigui; BURK, Robert David; FERREIRA, Luiz Carlos Lima. HPV Infection and Cervical Screening in Socially Isolated Indigenous Women Inhabitants of the Amazonian Rainforest. PLoS ONE, v. 10, n. 7, p. e0133635 , 2015en_US
dc.publisherPublic Library of Scienceen_US
dc.rightsopen accessen_US
dc.subject.otherRegião Amazônicaen_US
dc.subject.otherDoenças e Agravos Não Transmissíveisen_US
dc.titleHPV Infection and Cervical Screening in Socially Isolated Indigenous Women Inhabitants of the Amazonian Rainforesten_US
dc.description.abstractenObjective Indigenous women from the Amazon regions have some of the highest rates of cervical cancer in the world. This study evaluated cervical cytology and human papillomavirus (HPV) in native women that differ by lifestyle and interaction with western society. Yanomami women are isolated deep in the Amazon with a hunter/gatherer lifestyle. Macuxi and Wapishana women live in proximity to western society. Methods To select a representative group of women from each district, random cluster sampling was used, considering each registered village as a cluster. Cervical samples were collected for cytology and HPV detection and typing by PCR amplification and next generation sequencing. The study was approved by the National IRB and by tribal leaders. Results 664 native women were enrolled from 13 indigenous villages (76% participation rate). Yanomami women had higher rates of abnormal cytology (5.1% vs. 1.8%, p = 0.04) and prevalent HR-HPV (34.1% vs. 19.2%, p<0.001). Yanomami women >35y of age were significantly more likely to have HR-HPV, whereas women ≤35y did not significantly differ between groups. Prevalence of HPV was significantly different amongst geographically clustered Yanomami women (p<0.004). The most prevalent HPV types in the entire group were HPV31 (8.7%), HPV16 (5.9%) and HPV18 (4.4%). Conclusion Isolated endogenous Yanomami women were more likely to be HPV+ and rates increased with age. Study of HPV in isolated hunter-gather peoples suggests that long-term persistence is a characteristic of prehistoric humans and patterns reflecting decreased prevalence with age in western society represents recent change. These studies have implications for cervical cancer prevention and viral-host relationships.en_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsAmostragem aleatóriaen_US
dc.subject.decsDNA Viralen_US
dc.subject.enHealth of Indigenous Peoplesen_US
dc.subject.enIndians, South Americanen_US
dc.subject.enCluster Samplingen_US
dc.subject.enDNA, Viralen_US
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