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Title: Cytotoxic, genotoxic and mutagenic evaluation of Alibertia edulis (rich.) a. Rich. ex DC: an indigenous species from Brazil
Authors: Tolouei, Sara Emilia Lima
Traesel, Giseli Karenina
Freitas de Lima, Fernando
Souza de Araújo, Flávio Henrique
Honaiser Lescano, Caroline
Cardoso, Claudia Andrea Lima
Oesterreich, Silvia Aparecida
Vieira, Maria do Carmo
Abstract: Tea leaves of Alibertia edulis is popularly used in folk medicine. However, studies on the genotoxicity of this plant are not available. We aimed to investigate the in vivo and in vitro cytotoxic, genotoxic and mutagenic potentials of the aqueous extract of A. edulis leaves (AEAE). Antioxidant assays, the Artemia salina test, MTT in human platelets, micronucleus in bone marrow and comet in peripheral blood were performed. Animals received four different doses of the AEAE by oral gavage for 30 days. Saline and cyclophosphamide were used as controls. The AEAE exhibited a maximal inhibition at 100 and 250 µg/mL, according to the ABTS and DPPH methods, respectively. The A. salina assay showed that the AEAE presented some toxicity at doses of 100, 250 and 500 μg/mL. Through the MTT assay, the AEAE showed no toxic effects on human platelets during the incubation period. The alkaline comet assay showed that all doses of the AEAE were statistically similar to the negative control group since they did not induce any significant increase of the overall number of damaged cells nor the severity of the cell damage. In the micronucleous assay, results demonstrate that the AEAE did not increase the production of micronucleated polychromatic erythrocytes and was statistically similar to the negative control. The four doses of the plant extract did not affect the production of new erythrocytes and were statistically similar to the negative control groups. Furthermore, the AEAE demonstrated no cytotoxicity, genotoxicity and mutagenicity at the doses tested in rats
Keywords: Artemia Salina
Keywords: Região Centro-Oeste
Mato Grosso do Sul
Doenças e Agravos Não Transmissíveis
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Medicina Tradicional
Plantas Medicinais
Testes de Toxicidade
Issue Date: 2018
Publisher: Elsevier
Citation: TOLOUEI, Sara Emilia Lima; et al. Cytotoxic, genotoxic and mutagenic evaluation of Alibertia edulis (rich.) a. Rich. ex DC: an indigenous species from Brazil. Drug and Chemical Toxicology, v. 43, n. 2 , p. 200-207, 2018
ISSN: 10.1080/01480545.2018.1488862
Other Identifiers: 10.1080/01480545.2018.1488862
Copyright: open access
Appears in Collections:DANT - Artigos de Periódicos

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