Use este identificador para citar ou linkar para este item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/6745
Título: Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population
Autor(es): Hadi, Syeda Anum
Kolte, Ida Viktoria
Brenner, Evan
Cunha, Eunice A. Totumi
Simonsen, Vera
Ferrazoli, Lucilaine
Villela, Daniel A. Maciel
Santos, Reinaldo Souza dos
Ravi, Janani
Sreevatsan, Srinand
Basta, Paulo Cesar
Afiliação: Michigan State University. College of Veterinary Medicine. Michigan, USA.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.
Michigan State University. College of Veterinary Medicine. Michigan, USA
Laboratório Central de Saúde Pública de Mato Grosso do Sul. Campo Grande, MS, Brasil
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Instituto Adolfo Lutz. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil
Michigan State University. College of Veterinary Medicine. Michigan, USA
Michigan State University. College of Veterinary Medicine. Michigan, USA
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil
Resumo em inglês: Abstract After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay and the Brazilian state of Mato Grosso do Sul . This community, marginalized in Brazilian society, experiences severe poverty. Like other South American indigenous populations, their TB prevalence is high, but the disease has remained largely unstudied in their communities. Herein, Mycobacterium tuberculosis isolates from local clinics were whole genome sequenced, and a population genetic framework was generated. Phylogenetics show M. tuberculosis isolates in the Guarani-Kaiowá people cluster away from selected reference strains, suggesting divergence. Most cluster in a single group, further characterized as M. tuberculosis sublineage 4.3.3. Closer analysis of SNPs showed numerous variants across the genome, including in drug resistance-associated genes, and with many unique changes fixed in each group. We report that local M. tuberculosis strains have acquired unique polymorphisms in the Guarani-Kaiowá people, and drug resistance characterization is urgently needed to inform public health to ensure proper care and avoid further evolution and spread of drug-resistant TB.
Palavras-chave em inglês: Brazil
Health of Indigenous Peoples
Indians, South American
Tuberculosis
Vulnerable Populations
Palavras-chave: Região Centro-Oeste
Mato Grosso do Sul
Guarani Kaiowá
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Tuberculose
Mycobacterium tuberculosis
Populações Vulneráveis
Data do documento: 2021
Editor: Nature Publishing Group
Referência: HADI, Syeda Anum et al. Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population. Scientific Reports, v. 11, n. 1, p. 1-12, 2021.
DOI: 10.1038/s41598-020-79621-3
ISSN: 2045-2322
Direito autoral: open access
Aparece nas coleções:DIP - Artigos de Periódicos

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