Please use this identifier to cite or link to this item: http://ds.saudeindigena.icict.fiocruz.br/handle/bvs/6745
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dc.contributor.authorHadi, Syeda Anum-
dc.contributor.authorKolte, Ida Viktoria-
dc.contributor.authorBrenner, Evan-
dc.contributor.authorCunha, Eunice A. Totumi-
dc.contributor.authorSimonsen, Vera-
dc.contributor.authorFerrazoli, Lucilaine-
dc.contributor.authorVillela, Daniel A. Maciel-
dc.contributor.authorSantos, Reinaldo Souza dos-
dc.contributor.authorRavi, Janani-
dc.contributor.authorSreevatsan, Srinand-
dc.contributor.authorBasta, Paulo Cesar-
dc.date.accessioned2022-03-29T18:02:30Z-
dc.date.available2022-03-29T18:02:30Z-
dc.date.issued2021-
dc.identifier.citationHADI, Syeda Anum et al. Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population. Scientific Reports, v. 11, n. 1, p. 1-12, 2021.en_US
dc.identifier.issn2045-2322-
dc.identifier.urihttp://ds.saudeindigena.icict.fiocruz.br/handle/bvs/6745-
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.rightsopen accessen_US
dc.subject.otherRegião Centro-Oesteen_US
dc.subject.otherMato Grosso do Sulen_US
dc.subject.otherGuarani Kaiowáen_US
dc.titleIdentification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous populationen_US
dc.typeArticleen_US
dc.creator.affilliationMichigan State University. College of Veterinary Medicine. Michigan, USA.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationMichigan State University. College of Veterinary Medicine. Michigan, USAen_US
dc.creator.affilliationLaboratório Central de Saúde Pública de Mato Grosso do Sul. Campo Grande, MS, Brasilen_US
dc.creator.affilliationInstituto Adolfo Lutz. São Paulo, SP, Brasil.en_US
dc.creator.affilliationInstituto Adolfo Lutz. São Paulo, SP, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.en_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasilen_US
dc.creator.affilliationMichigan State University. College of Veterinary Medicine. Michigan, USAen_US
dc.creator.affilliationMichigan State University. College of Veterinary Medicine. Michigan, USAen_US
dc.creator.affilliationFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasilen_US
dc.description.abstractenAbstract After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay and the Brazilian state of Mato Grosso do Sul . This community, marginalized in Brazilian society, experiences severe poverty. Like other South American indigenous populations, their TB prevalence is high, but the disease has remained largely unstudied in their communities. Herein, Mycobacterium tuberculosis isolates from local clinics were whole genome sequenced, and a population genetic framework was generated. Phylogenetics show M. tuberculosis isolates in the Guarani-Kaiowá people cluster away from selected reference strains, suggesting divergence. Most cluster in a single group, further characterized as M. tuberculosis sublineage 4.3.3. Closer analysis of SNPs showed numerous variants across the genome, including in drug resistance-associated genes, and with many unique changes fixed in each group. We report that local M. tuberculosis strains have acquired unique polymorphisms in the Guarani-Kaiowá people, and drug resistance characterization is urgently needed to inform public health to ensure proper care and avoid further evolution and spread of drug-resistant TB.en_US
dc.identifier.doi10.1038/s41598-020-79621-3-
dc.subject.decsBrasilen_US
dc.subject.decsSaúde de Populações Indígenasen_US
dc.subject.decsÍndios Sul-Americanosen_US
dc.subject.decsTuberculoseen_US
dc.subject.decsMycobacterium tuberculosisen_US
dc.subject.decsPopulações Vulneráveisen_US
dc.subject.enBrazilen_US
dc.subject.enHealth of Indigenous Peoplesen_US
dc.subject.enIndians, South Americanen_US
dc.subject.enTuberculosisen_US
dc.subject.enVulnerable Populationsen_US
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