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Title:	Epidemiology of rotavirus gastroenteritis in the Amazon region and the need for a specific vaccine
Authors:	Linhares, Alexandre da Costa Gabbay, Yvone Benchimol Mascarenhas, Joana D'Arc Pereira Freitas, Ronaldo Barros de Oliveira, Consuelo Silva de Bellesi, Newton Monteiro, Talita Antônia Furtado
Affilliation:	Fundação Nacional de Saúde (Brasil). Instituto Evandro Chagas. Belém, PA, Brasil Fundação Nacional de Saúde (Brasil). Instituto Evandro Chagas. Belém, PA, Brasil Fundação Nacional de Saúde (Brasil). Instituto Evandro Chagas. Belém, PA, Brasil Fundação Nacional de Saúde (Brasil). Instituto Evandro Chagas. Belém, PA, Brasil Fundação Nacional de Saúde (Brasil). Instituto Evandro Chagas. Belém, PA, Brasil Clinica de Medicina Preventiva do Pará, Belém, PA, Brasil Fundação Nacional de Saúde (Brasil). Instituto Evandro Chagas. Belém, PA, Brasil
Abstract:	In the Amazon region, rotaviruses account for at least 30 per cent of all episodes of acute gastroenteritis among hospitalized children and are associated with nearly 1O per cent of cases of infantile acute diarrhea at community level. All four rotavirus serotypes are shown to infect children in our region, serotype l being predominant (about 50 per cent). Sequential infections in the same child, caused by different serotypes, are commonly noted. No clear seasonal variation on the occurrence of rotavirus diarrhea has been recorded, as cases are readily detected throughout the year. Rotavirus diarrhea cases have been found to be, in general, more severe than those of other aetiology. On the other hand, it has been noted that early (children less than 4 months of age) rotavirus infections are more likely to be asymptomatic (p = 0.021). Occurrence of rotavirus infections among Amazonian Indian populations seems to be very common. An explosive outbreak of rotavirus diarrhea affected possibly 88 per cent of both children and adults of the Tiryió population, Northern Pará State. In addition, rotavirus antibody was detected in 54.7 per cent of 1,299 sera collected from Amerinds belonging to 13 relatively isolated communities in the Amazon region. In the light of the above mentioned findings it was suggested that our region would be suitable for a field trial with a rotavirus-candidate vaccine. A study is therefore underway aiming to compare safety, immunogenicity and efficacy of a rhesus-human reassortant rotavirus (RRV-tetravalent) vaccine and placebo in 500 healthy infants living in the peripheral area of Belém.
Keywords:	Brazil Health of Indigenous Peoples Indians, South American Rotavirus Infections Gastroenteritis Rotavírus
Keywords:	Região Amazônica Gastroenterite Rotavírus
DeCS:	Brasil Saúde de Populações Indígenas Índios Sul-Americanos Infecções por Rotavirus Gastroenterite Rotavírus
Issue Date:	1992
Publisher:	Sociedade Brasileira para o Progresso da Ciência
Citation:	LINHARES, Alexandre da Costa; et al. Epidemiology of rotavirus gastroenteritis in the Amazon region and the need for a specific vaccine. Ciência e Cultura, São Paulo, v. 44, n. 2/3, p. 152-157, 1992.
ISSN:	0009-6725
Other Identifiers:	0009-6725
Copyright:	open access
Appears in Collections:	DIP - Artigos de Periódicos

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