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Title:	Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians
Authors:	Fujiyoshi, Toshinobu Yashiki, Shinji Fujiyama, Chihaya Kuwayama, Masahiro Miyashita, Hiroki Ohnishi, Hiroshi Blank, Michelle Zaninovic, Vladimir Blank, Abraham Cartier, Luis Byrnes, John J. Harrington Jr., William J. Miura, Tomoyuki Hayami, Masanori Tajima, Kazuo Sonoda, Shunro
Affilliation:	Kagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan. Kagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan. Kagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan. Kagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan. Kagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan. Sumitomo Metal Industries. Bio-medical Division. Tokyo, Japan. Kagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan. University of Valle. Faculty of Medicine. Department of Clinical Neurology. Cali, Colombia. University of Valle. Cell Biology Division. Cali, Colombia. University of Chile. Faculty of Medicine. Department of Neurology. Santiago, Chile. University of Miami. Miami, FL, USA. University of Miami. Miami, FL, USA. Kyoto University. Institute for Virus Research. Kyoto, Japan. Kyoto University. Institute for Virus Research. Kyoto, Japan. Aichi Cancer Center Research Institute. Division of Epidemiology. Nagoya, Japan. Kagoshima University. Faculty of Medicine. Department of Virology. Kagoshima, Japan.
Abstract:	Thd investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-IIhd carriers among South American native Indians, we analyzed HLA DRBI*-DQBI * haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These reults suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections.
Issue Date:	1995
Publisher:	Wiley
Citation:	FUJIYOSHI, Toshinobu et al. Ethnic segregation of HTLV-I and HTLV-II carriers among South American native Indians. International Journal of Cancer, v. 63, n. 4, p. 510-515, 15 nov. 1995.
Description:	"To investigate the genetic background of human T-cell leukemia virus type I (HTLV-I) and II (HTLV-IIhd carriers among South American native Indians, we analyzed HLA DRBI*-DQBI bin gdrive log saida TED-SESAI_Coimbra1.csv TED-SESAI_Coimbra2.csv TED-SESAI_Coimbra2.csv.orig xml haplotypes of the virus carriers from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping method. It was revealed that the HTLV-I-carrying Andes natives had one of the 5 HLA haplotypes: DRBI*-DQBI* 0403-0302, 0802-0402, 0901-0303, 1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one of the 3 HLA haplotypes: DRBI*-DQBI* 1402-0301, 1602-0301 and 0404-0302. The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers were mutually exclusive. The haplotypes associated with HTLV-I carriers were commonly found among the Andes Indians and Japanese, which is the known HTLV-I endemic population, while the haplotypes associated with HTLV-II carriers were specifically found among the Orinoco Indians and North American Indians, among whom HTLV-II is endemic. These reults suggested that HLA haplotypes might be ethnically segregated among South American natives and might be involved in the susceptibility to HTLV-I and HTLV-II infections."
metadata.dc.identifier.doi:	10.1002/ijc.2910630409
ISSN:	0020-7136
Copyright:	restricted access
Appears in Collections:	TR - Artigos de Periódicos

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