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Title: Levels of complement C3 and C4 components in Amerindians living in an area with high prevalence of tuberculosis
Authors: Araujo, Zaida
González, Nieves
Cubeddu, Laura de
Ziegler, Rita C.
Waard, Jacobus H. de
Giampietro, Francesca
Garzaro, Domingo
Pujol, Flor H.
Serrano, Neligia Carrasco de
Saboin, Amairany García de
Abstract: The levels of complement C3 and C4 components were determined in non-indigenous (creoles) and indigenous (Warao) populations, the latter with an extremely high tuberculosis (TB) rate. Serum samples from 209 adults were studied and classified in 4 groups taking into account tuberculin skin tests (TST): (1) the group of Warao patients (58 positive for the TST, WP TST+ and 9 negative for the TST, WP TST–), (2) the group of creole patients (34 positive for the TST, CP TST+ and 9 negative for the TST, CP TST–), (3) the group of healthy Warao controls (38 positive and 14 negative for TST, WC TST+ and WC TST–, respectively), (4) the creole controls (26 positive and 21 negative for the TST, CC TST+ and CC TST–, respectively). With respect to the results concerning the measurement of both complement C3 and C4 components with the exception of the WC TST– and the CC groups, the WP TST+ and WP TST– as well as WC TST+ groups showed a significant frequency of individuals with decreased levels of complement C3 component (20.6, 33.3, and 26.3%, respectively) and also C4 component (12.0, 11.1, and 13.3%, respectively) in comparison to both creole patients (CP TST+, 8.82% and CP TST–, 0% and CP TST+, 5.88% and CP TST–, 0%) for C3 and C4, respectively. The study of these parameters carried out in 15 Warao subjects with active infection, before and after anti-TB chemotherapy, statistically confirmed that the effective chemotherapy did not restore normal levels of the complement C3 and C4 components among Warao patients. Aditional tests for hepatitis B or hepatitis C infection, and the profile of the hepatic proteins were not associated to the deficiency in production of the complement components. In conclusion, the results show that within the Warao population, a high percentage of subjects exhibit decreased levels of both complement C3 and C4 components independent of latent or active infection and the status of TST.
Keywords: Brazil
Body Mass Index
Complement C3 and C4 components
Health of Indigenous Peoples
Indians, South American
Keywords: Warao
Estudo das Minorias
DeCS: Brasil
Saúde de Populações Indígenas
Índios Sul-Americanos
Complemento C3
Índice de Massa Corporal
Doenças Infecciosas
Complemento C4
Issue Date: 2006
Publisher: Fundação Oswaldo Cruz
Citation: ARAUJO, Zaida; et al. Levels of complement C3 and C4 components in Amerindians living in an area with high prevalence of tuberculosis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 359-364, 2006
metadata.dc.identifier.doi: 10.1590/S0074-02762006000400003
ISSN: 0074-0276
Other Identifiers: 10.1590/S0074-02762006000400003
Copyright: open access
Appears in Collections:DIP - Artigos de Periódicos

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